新陈代谢是机体的根本生命活动,而循环系统则是保证机体新陈代谢正常进行的基本运输线,心脏是动力器官,为物质运送和交换提供动力。如心脏发生障碍,可引起全身各种组织器官血液供应不足、产生缺血、缺氧或变性坏死等一系列病理改变和临床症状,严重时可危及生命。药源性心脏障碍也是这样,因此了解药物对心脏的不良影响,对于避免或及早发现药源性心脏障碍有重要意义。药物对心脏的不良反应可分为毒性反应和变态反应二类。心脏变态反应很少见,往往是全身过敏反应的一部分;如在心脏障碍时,同时发生皮炎、关节炎等药物变态反应表现,就可考虑为药源性变态反应心脏障碍。甚至只有心电图改变和显著的血液嗜酸性白细胞增多二项就可作出初步诊断。药物变态反应性 Metabolism is the basic life activity of the body, while the circulatory system is the basic transport line to ensure the normal metabolism of the body, the heart is the power organ, which provides power for the material delivery and exchange. Such as heart failure, can cause systemic blood supply to various tissues and organs, resulting in ischemia, hypoxia or degeneration and necrosis and a series of pathological changes and clinical symptoms, serious life-threatening. The same is true of drug-induced heart disease, so understanding the adverse effects of drugs on the heart is important for avoiding or early detection of drug-induced heart disorders. Adverse drug reactions to the heart can be divided into two types of toxic reactions and allergies. Cardiac allergies are rare and are often part of a systemic anaphylactic reaction; such as dermatitis, arthritis and other allergic manifestations of heart disease, can be considered as drug-induced allergic heart disorders. Even the ECG changes and significant blood eosinophilia binomial can make a preliminary diagnosis. Drug allergy