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1963年,Reye等所描述的一种具有临床-病理特征的疾病,现在被称为的Reye综合征(内脏脂肪变性和脑病)。该病通常先有前驱表现,流感或水痘,然后于感染后3～5天,以恶性呕吐起病,易激动和嗜睡,但定向良好。血清转氨酶升高3～30倍,血清胆红素多正常,血氨浓度不定,非昏迷病人有轻、中度升高,为正常的2～5倍或不升高,昏迷病人血氨浓度均上升为正常的3～20倍,脑病典型地持续24～96小时,幸存者逐渐恢复,有永久性神经损伤者的神志恢复约需数周。
In 1963, Reye et al described a clinically-pathological feature of the disease, now called Reye syndrome (visceral steatosis and encephalopathy). The disease is usually preceded by a precursor manifestation of flu or chicken pox and then onset with vomiting 3 to 5 days after infection, irritable and lethargic but well oriented. Serum aminotransferase increased 3 to 30 times more normal serum bilirubin, blood ammonia concentration is variable, non-coma patients have mild to moderate increase of 2 to 5 times normal or not increased, coma patients in the concentration of ammonia are Rose to normal 3 to 20 times, encephalopathy typically lasts for 24 to 96 hours, the survivors gradually recover, and those with permanent nerve damage recover in about several weeks.