论文部分内容阅读
目的:研究参芪扶正注射液对重症急性胰腺炎(SAP)的治疗作用。方法:66只Wistar大鼠随机分为:SAP假手术组(SO组),SAP模型组(SAP组)和参芪扶正注射液治疗组(SQ组),胆胰管逆行注射50g.l~(-1)牛磺胆酸钠复制大鼠SAP模型。造模成功后2、4、8、12、24 h检测血清中TNF-α、IL-6和ALT水平,观察肝脏组织病理改变。结果:与SO组相比,SAP组及SQ组血清中TNF-α、IL-6和ALT水平明显升高(P<0.05)。与SAP组相比,从8 h开始SQ组血清中TNF-α、IL-6和ALT水平开始下降(P<0.05),两组的肝脏病理改变无统计学意义。结论:参芪扶正注射液可以降低SAP时血清中ALT、TNF-α和IL-6水平,但不能改善肝脏组织的病理损伤程度,对SAP的发生、发展可能有一定的预防作用。
Objective: To study the therapeutic effect of Shenqi Fuzheng Injection on severe acute pancreatitis (SAP). METHODS: Sixty-six Wistar rats were randomly divided into SAP sham operation group (SO group), SAP model group (SAP group) and Shenqi Fuzheng injection treatment group (SQ group). The bile ducts and pancreatic ducts were injected retrogradely with 50g.l~( -1) Sodium taurocholate replicates rat SAP model. The levels of TNF-α, IL-6 and ALT in serum were detected at 2, 4, 8, 12 and 24 h after modeling, and the pathological changes of liver tissue were observed. Results: Compared with SO group, serum TNF-α, IL-6 and ALT levels in SAP group and SQ group were significantly higher (P<0.05). Compared with SAP group, serum TNF-α, IL-6 and ALT levels began to decrease in SQ group from 8 h (P<0.05). There was no statistical difference in liver pathological changes between the two groups. Conclusion: Shenqi Fuzheng Injection can reduce the levels of ALT, TNF-α and IL-6 in serum during SAP, but it can not improve the degree of pathological damage of liver tissue. It may have certain preventive effect on the occurrence and development of SAP.