呼吸机相关肺损伤引起肺泡上皮细胞通透性改变、肺组织水肿,可能导致三磷酸腺苷(ATP)供需平衡紊乱,嘌呤类代谢产物释放增加等病理生理改变。本试验作者以SD大鼠为研究对象,旨在明确肺组织释放的嘌呤类代谢产物是否可以反映机械通气所致肺水肿及早期肺泡上皮受损的组织代谢变化,是否可以作为反映呼吸机相关肺损伤后肺形态学改变和肺组织早期受损的指标。采用前瞻性、随机、对照试验,用单因素方差分析法进行统计学处理。 方法:将SD大鼠分成6组,设定通气条件。第1组吸气 Ventilator-associated lung injury caused alveolar epithelial cell permeability changes, pulmonary edema, which may lead to disorders of supply and demand balance of ATP and increase of pathophysiological changes of purine metabolites. The purpose of this study was to determine whether purine metabolites released by lung tissue can reflect pulmonary edema induced by mechanical ventilation and tissue metabolism changes in early stage of alveolar epithelial damage, Lung morphological changes and indicators of early lung damage after injury. A prospective, randomized, controlled trial was used for statistical analysis using one-way analysis of variance (ANOVA). Methods: The SD rats were divided into 6 groups to set the ventilation conditions. Group 1 inhale