检测人癌症中活化的癌基因往往令人失望。现在只有百分之几的实体瘤中发现致癌基因,而实体瘤在人癌中占绝大多数。这一发现对致癌基因在癌症中起主要作用的观点产生怀疑。然而,研究人员现已发现,在外科手术切除的结肠癌中约有40％含有活性的ras致癌基因。此外,研究结果表明,瘤发生过程中,基因活化的发生较早。 Detection of activated oncogenes in human cancers is often disappointing. Only a few percent of solid tumors are now found to have oncogenes, and solid tumors account for the vast majority of human cancers. This finding raises doubts about the role of oncogenes in cancer. However, researchers have now found that approximately 40% of surgically resected colon cancers contain active ras oncogenes. In addition, the results of the study indicate that gene activation occurred earlier in the process of tumorigenesis.