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本文观察了120只615系小鼠可移植性乳腺癌肺转移的组织形态学特征。转移瘤依肺内位置分为中央、周围及混合三类,均为较大血管型肺转移。与皮下移植瘤相比,肺转移瘤内低分化瘤的比例增加。同一小鼠肺转移灶间、甚或同一转移灶的不同区域间,肿瘤分化程度和细胞形态并不是同质性的。实验结果提示,移植部位瘤细胞团向血管内形成乳头状突起并大块脱落,是造成小鼠乳腺癌较大血管型肺转移的原因,并因之导致肺转移瘤组织形态的不一致;易发生转移的是亲代肿瘤中分化较差的部分;肿瘤转移灶形成过程中瘤组织似存在着失分化和再分化现象。
This article observed the histomorphological features of lung metastases from transplantable breast cancer in 615 mice. Metastatic tumors were divided into three groups according to the location of the lungs: central, peripheral, and mixed. All of them were larger vascular lung metastases. Compared with subcutaneous tumors, the proportion of poorly differentiated tumors in lung metastases increases. Between the same mouse lung metastases, or even different regions of the same metastasis, the degree of tumor differentiation and cell morphology are not homogeneous. The experimental results suggest that the formation of papillary protrusions and massive detachment of tumor cell clusters in the blood vessels at the transplant site is the cause of the greater vascular lung metastasis of the mouse breast cancer, and the resulting inconsistent tissue morphology of the lung metastases; The poorly differentiated part of the parental tumor was metastasized; there appeared to be dedifferentiation and redifferentiation of the tumor tissue during the formation of tumor metastases.