目的为深入探讨颈肩痛的发病机理。方法用免疫组织化学方法观察人颈段脊柱结构内CGRP和SP阳性神经末梢存在的情况。结果人颈段脊柱结构的纤维层内均有CGRP和SP免疫反应阳性神经末梢存在,多数神经末梢独立行走,呈树枝状或念珠状,少量神经末梢交织网状。结论CGRP和SP可能参与了人颈段脊柱结构的伤害性感觉信息的传递。当人颈段脊柱结构的神经末梢受刺激时,可能引起CGRP和SP的释放和传递,这可能是引起原发性颈肩痛的原因之一。 The purpose is to explore in depth the pathogenesis of neck and shoulder pain. Methods Immunohistochemistry was used to observe the presence of CGRP and SP positive nerve endings in human cervical spine. Results There were CGRP and SP immunoreactive nerve endings in the fibrous layer of human cervical spine. Most of the nerve endings walked independently, showing dendrites or rosary. A few nerve endings were interlaced. Conclusion CGRP and SP may be involved in the transmission of nociceptive information in the cervical spine of human cervical spine. When the nerve endings of human cervical spine structure are stimulated, it may cause the release and transmission of CGRP and SP, which may be one of the causes of primary neck and shoulder pain.