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目前大量分子靶向药物运用于转移性肾癌,但在局部进展期肾癌中的应用尚未被证实。对局部进展期肾癌有效的分子靶向药物,应既能降低原发灶分期,又能阻止肿瘤转移。在此对临床试验进行总结,评估分子靶向药物对原发肿瘤的减瘤能力,探究分子靶向药物阻止肿瘤转移的证据,为局部进展期肾癌辅助治疗提供更多理论依据。
At present a large number of molecular targeted drugs used in metastatic renal cell carcinoma, but in locally advanced renal cell carcinoma has not been confirmed. Effective molecular targeted drugs for locally advanced renal cell carcinoma should not only reduce the staging of primary tumors, but also prevent tumor metastasis. Here we summarize the clinical trials, evaluate the ability of molecular targeted drugs to reduce the tumor of primary tumors, explore the evidence of molecular targeted drugs to prevent tumor metastasis, and provide more theoretical basis for the adjuvant treatment of locally advanced renal cell carcinoma.