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用HBsAg及HBeAg均阳性的乙肝病人血清接种40只树鼩。4周后有32只(80％)血清HBsAg和/或抗-HBc阳性,其SGPT活性显著升高。将这32只动物随机分成3组:两组为实验组,每只动物每天注射肝灵一次,共21天,一组为对照组。到实验第11周时,实验组动物SGPT值显著下降,HBV转阴率高;而对照组不明显。本实验进一步证实树鼩能感染人的HBV;同时表明肝灵注射液对乙型肝炎有一定的疗效。
HBsAg and HBeAg positive hepatitis B patients were inoculated with 40 tree shrews. After 4 weeks, there were 32 (80%) serum HBsAg and/or anti-HBc positive, and their SGPT activity was significantly increased. The 32 animals were randomly divided into 3 groups: the two groups were experimental groups, each animal was injected with liver spirit once a day for 21 days, and one group was a control group. By the 11th week of the experiment, the SGPT value of the experimental group was significantly decreased, and the HBV negative rate was high, but it was not obvious in the control group. This experiment further confirmed that tree shrew can infect human HBV; at the same time, it shows that Ganling Injection has a certain effect on hepatitis B.