以天然低密度脂蛋白(nLDL) 为对照组, 探讨了氧化修饰低密度脂蛋白(oxLDL)对人外周血单核细胞(PBMs) 和人前单核白血病细胞株THP1 粘附和分泌功能的影响。结果表明: oxLDL可上调单核细胞粘附分子CD11b 表达, 促进其与内皮的粘附, 并进一步诱导TNFα、IL8 的分泌; 而nLDL无此作用。说明oxLDL是单核细胞粘附和激活的诱导剂, 经oxLDL诱导的THP1 表现出与成熟单核巨噬细胞相似的特征, 可作为体外动脉粥样硬化单核细胞分化激活的细胞模型 To investigate the effect of oxidized low density lipoprotein (oxLDL) on the adhesion and secretion of human peripheral blood mononuclear cells (PBMs) and human monocytic leukemia cell line THP1 by using natural low-density lipoprotein (nLDL) as control group influences. The results showed that: oxLDL can up-regulate the expression of monocyte adhesion molecule CD11b to promote its adhesion with the endothelium, and further induce the secretion of TNF @, IL-8; and nLDL without this effect. That oxLDL is monocyte adhesion and activation of the inducer, induced by oxLDL THP  1 showed similar characteristics of mature monocytes  macrophages can be used as atherogenic monocyte differentiation in vitro activation of cell models