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目的:探讨重度子痫前期患者心脏形态及功能的变化。方法:早发型重度子痫前期46例,晚发型重度子痫前期62例,正常妊娠86例,比较彩色多普勒心脏超声结果中各指标的差异来评估心脏形态及功能的变化。结果:与正常妊娠组相比,晚发型重度子痫前期组左心各径线明显增大,差异有统计学意义(P<0.05);收缩期指标差异无统计学意义(P>0.05),但4例LVEF<55%;舒张期指标显著降低,差异有统计学意义(P<0.01);心包积液发生率显著增高,差异有统计学意义(P<0.05)。早发型重度子痫前期比晚发型左房增大更显著,差异有统计学意义(P<0.01)。结论:重度子痫前期患者心脏形态改变以左房室腔增大、室壁及室间隔增厚、心包积液为主,伴左室舒张功能的损害,个别病例收缩功能轻度受损。早发型重度子痫前期心血管损害程度超过晚发型。
Objective: To investigate the changes of cardiac morphology and function in patients with severe preeclampsia. Methods: Early onset severe preeclampsia in 46 cases, late onset severe preeclampsia in 62 cases, normal pregnancy in 86 cases, color Doppler echocardiographic results in the difference between the various indicators to assess the changes in cardiac morphology and function. Results: Compared with normal pregnancy group, the diameters of left heart in late-onset severe preeclampsia group were significantly increased (P <0.05), but there was no significant difference in systolic index (P> 0.05) However, the LVEF was lower than 55% in 4 cases. The diastolic index was significantly lower (P <0.01). The incidence of pericardial effusion was significantly higher (P <0.05). Early-onset severe preeclampsia than late-onset left atrial enlargement more significantly, the difference was statistically significant (P <0.01). Conclusion: The changes of heart shape in patients with severe preeclampsia are mainly caused by the increase of left atrioventricular cavity, thickening of ventricular wall and ventricular septum, pericardial effusion and diastolic function of left ventricle, and slight impairment of individual systolic function. Early onset of severe preeclampsia cardiovascular damage than late-onset type.