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应用流式细胞术对３４例甲状腺滤泡性肿瘤Ｐ５３蛋白表达进行定量研究，结果：滤泡性腺瘤与滤泡性癌的Ｐ５３蛋白阳性率均较高，无明显统计学差异。但滤泡性癌的Ｐ５３蛋白表达量（ＦＩ值）明显高于胚胎和胎儿型腺瘤（Ｐ＜０．０５），而与滤泡性腺瘤增生活跃组相比，无统计学差异，但该组有３例呈Ｐ５３蛋白高表达，经多次切片仔细观察，有２例被确诊为滤泡性癌，另１例细胞异型性明显，建议随访。提示：Ｐ５３蛋白的阳性表达是甲状腺滤泡性肿瘤的一种常见现象，而Ｐ５３蛋白高表达可作为区别良恶性滤泡性肿瘤的重要标志。
Flow cytometry was used to quantitatively study the expression of P53 protein in 34 cases of thyroid follicular neoplasms. The results showed that the positive rates of P53 protein in follicular adenomas and follicular carcinomas were high, and there was no significant difference. However, the expression of P53 protein in follicular carcinoma (FI value) was significantly higher than that in embryonic and fetal adenoma (P<0.05), but there was no statistical difference compared with the follicular adenoma hyperplasia group. There were 3 cases of high expression of P53 protein, after careful observation of multiple slices, there were 2 cases were diagnosed as follicular carcinoma, and the other one cell was obvious, suggesting follow-up. Tip: The positive expression of P53 protein is a common phenomenon in follicular thyroid tumors, and the high expression of P53 protein can be used as an important marker to distinguish between benign and malignant follicular tumors.