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通过对庆大霉素和甲硝唑药物动力学的测定，阐明口服联合全身性给药方案的合理性。采用标准测定仪器及庆大霉素、甲硝唑标准品，将大肠癌患者分为两组，A组为口服给药组，B组为口服联合静脉给药组，于手术前、中、后给药后，测定患者血清及组织药物浓度，并进行对照。结果：A组术后感染2例，B组无1例感染；A组患者血清庆大霉素及组织庆大霉素含量均未测出，甲硝唑浓度亦较低，B组血清庆大霉素、甲硝哇及组织中浓度均维持于较高浓度。说明口服联合静脉给药比单独口服给药方案更合理。
Through the determination of gentamicin and metronidazole pharmacokinetics, clarify the rationality of oral combined systemic dosing regimen. Using standard measuring instruments and gentamicin and metronidazole standards, patients with colorectal cancer were divided into two groups: group A was given orally, and group B was given oral combined intravenous group before, during, and after surgery. After administration, patient serum and tissue drug concentrations were measured and compared. RESULTS: In group A, there were 2 cases of postoperative infection, and in group B there was no infection. In group A, the serum gentamicin and gentamicin levels were not detected, the metronidazole concentration was also low, and the serum of group B was significantly increased. The concentrations of mycin, metronidazole and tissue were maintained at higher concentrations. This indicates that oral administration of intravenous administration is more reasonable than oral administration alone.