静注高剂量重组IL-2治疗转移癌常引起神经精神症状。往往使治疗受到限制。625例患者接受此法治疗,33％有定向力障础,5％有明显的昏迷症状。44例高剂最静注IL-2的患者,22例有严重的认知改变。频繁的焦虑不安、幻觉或明显的幻觉综合征。有报道在使用高剂量IL-2时,引起了血管漏出综合征,可进一步诱导心血管和肾功能的变化,导致静息时呼吸困难、无尿和低血压(需用血管加压素)。核磁共振像表明,用IL-2治疗后脑中水的成分增加,这可引起血管漏出综合征。这些机理有助于观测精神状况的变化。IFN-α Intravenous injection of high-dose recombinant IL-2 to treat metastatic cancer often causes neuropsychiatric symptoms. Treatment is often limited. 625 patients were treated with this method, 33% had an orientation barrier, and 5% had a significant coma. Of the 44 patients with high doses of the most intravenous IL-2, 22 had severe cognitive changes. Frequent anxiety, hallucinations or apparent hallucination syndrome. It has been reported that when high-dose IL-2 is used, a vascular leakage syndrome is caused, which can further induce changes in cardiovascular and renal functions, resulting in dyspnea at rest, anuria, and hypotension (vasopressin is required). MRI images show that after treatment with IL-2, the water content in the brain increases, which can cause vascular leakage syndrome. These mechanisms help to observe changes in mental conditions. IFN-α