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目的:检测104例乳腺癌组织内唾液酸的表达。方法:采用凝集素组织化学染色技术。结果:生物素化LPA(Limuluspolyphemusagglutinin)阳性率为56.7%(59/104);唾液酸的阳性表达与临床病理分期及淋巴结转移密切相关;在100例行根治性手术的乳腺癌中,45例LPA阴性患者的无瘤生存率明显高于55例LPA阳性患者(P<0.05)。结论:乳腺癌组织中,唾液酸的表达能够反映乳腺癌的恶性潜能,阳性表达是一项预后差的指标,生物素化LPA为判断乳腺癌预后提供了一种方便可靠的新方法。
Objective: To detect the expression of sialic acid in 104 cases of breast cancer. Methods: Lectin histochemical staining technique was used. Results: The positive rate of biotinylated LPA (Limulus polyphemus agglutinin) was 56.7% (59/104). The positive expression of sialic acid was closely related to clinical pathological stage and lymph node metastasis. Among 100 cases of breast cancer undergoing radical surgery, 45 The tumor-free survival rate of LPA-negative patients was significantly higher than that of 55 LPA-positive patients (P < 0.05). Conclusion: The expression of sialic acid in breast cancer tissues can reflect the malignant potential of breast cancer. Positive expression is a poor prognosis indicator. Biotinylated LPA provides a convenient and reliable new method for judging the prognosis of breast cancer.