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目的：检测１０４例乳腺癌组织内唾液酸的表达。方法：采用凝集素组织化学染色技术。结果：生物素化ＬＰＡ（Ｌｉｍｕｌｕｓｐｏｌｙｐｈｅｍｕｓａｇｇｌｕｔｉｎｉｎ）阳性率为５６．７％（５９／１０４）；唾液酸的阳性表达与临床病理分期及淋巴结转移密切相关；在１００例行根治性手术的乳腺癌中，４５例ＬＰＡ阴性患者的无瘤生存率明显高于５５例ＬＰＡ阳性患者（Ｐ＜０．０５）。结论：乳腺癌组织中，唾液酸的表达能够反映乳腺癌的恶性潜能，阳性表达是一项预后差的指标，生物素化ＬＰＡ为判断乳腺癌预后提供了一种方便可靠的新方法。
Objective: To detect the expression of sialic acid in 104 cases of breast cancer. Methods: Lectin histochemical staining technique was used. Results: The positive rate of biotinylated LPA (Limulus polyphemus agglutinin) was 56.7% (59/104). The positive expression of sialic acid was closely related to clinical pathological stage and lymph node metastasis. Among 100 cases of breast cancer undergoing radical surgery, 45 The tumor-free survival rate of LPA-negative patients was significantly higher than that of 55 LPA-positive patients (P < 0.05). Conclusion: The expression of sialic acid in breast cancer tissues can reflect the malignant potential of breast cancer. Positive expression is a poor prognosis indicator. Biotinylated LPA provides a convenient and reliable new method for judging the prognosis of breast cancer.