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目的:观察内蒙古大兴安岭地区人群乙肝疫苗免疫情况,免疫效果及乙肝表面抗原(HBsAg)携带情况,为进一步加强乙肝疫苗接种工作提供依据。方法:进行问卷调查,并收集血标本,应用酶联免疫(ELISA)法检测乙肝表面抗原(HBsAg)、乙肝表面抗体(Anit-HBs)。结果:内蒙古大兴安岭地区人群(年龄5~80岁)乙肝疫苗接种率36.00%,HB-sAg阳性率为7.38%,Anit-HBs阳性率为47.17%。免疫组HBsAg阳性率2.43%明显低于未免疫组HBsAg阳性率9.80%,差别有统计学意义(P<0.01);免疫组Anit-HBs阳性率64.77%明显高于未免疫组Anit-HBs阳性率38.52%,差别有统计学意义(P<0.01)。结论:我区开展乙肝疫苗接种工作减少了这段时期的感染。但乙肝疫苗接种率、Anit-HBs阳性率较低,故应加大乙肝疫苗接种工作宣传力度,加强乙肝疫苗接种质量,反复加强免疫可提高人群的免疫能力是预防乙肝病毒感染的有效途径。
Objective: To observe the immune status of hepatitis B vaccine, immune effect and HBsAg carrier of population in Daxinganling area of Inner Mongolia, so as to provide basis for further strengthening the hepatitis B vaccination. Methods: Questionnaires were collected and blood samples were collected. The HBsAg and Anit-HBs were detected by enzyme-linked immunosorbent assay (ELISA). Results: The vaccination rate of HBsAg was 36.00%, the positive rate of HBsAg was 7.38% and the positive rate of Anit-HBs was 47.17% in the population of Daxing’anling, Inner Mongolia (aged 5 ~ 80 years). The positive rate of HBsAg in immunized group was 2.43% which was significantly lower than that in non-immunized group (9.80%), the difference was statistically significant (P <0.01). The positive rate of Anit-HBs in immunized group was 64.77% 38.52%, the difference was statistically significant (P <0.01). Conclusion: Hepatitis B vaccination work in our district reduced the infection during this period. However, hepatitis B vaccination rate, Anit-HBs positive rate is low, it should increase hepatitis B vaccination efforts to promote and enhance the quality of hepatitis B vaccination, repeated immunization can improve the population’s immune capacity is an effective way to prevent hepatitis B virus infection.