作为糖尿病的內服药物Carbutamide(N_1—对氨苯磺酰—N_2—丁脲)、Tolbutamide(N_2—对甲氨苯磺酰—N_2—丁脲)并且选用Sulfanilamide(氨苯磺胺)作为对照,大量及超大量,即1日量0.5克/公斤及11.5克公斤,經过8周到16周分別經口投与大白鼠(Ratte),一方面观察此期间一般状况、血液像、Thorn試驗,发情周期、并且对肝脏及胰脏进行組織学检查,曾得到下述結果。 (1)一般状态:見到各組逐日精神不振、(?)毛、体重减輕、未见发疹及出血傾向。此现象在服用Carbutamide組最为明显。 (2)血液像:服用Carbutamide及Sulfa- Carbutamide (N-1-sulfanilamide-N-2-buthyl urea), Tolbutamide (N-2-p-aminothiazole-N-2-buthyl urea) and Sulfanilamide (sulfanilamide) Super large amount, ie 0.5g / kg and 11.5g kg on the 1st day, were administered orally to rats (Ratte) after 8 weeks to 16 weeks respectively. On the one hand, the general condition, blood picture, Thorn test and estrus cycle were observed, Histological examination of the liver and pancreas gave the following results. (1) The general state: see each group sluggish day by day, (?) Hair, weight loss, no rash and bleeding tendency. This phenomenon was most pronounced with Carbutamide. (2) blood like: taking Carbutamide and Sulfa-