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转化型生长因子β_1(Transforming growfh factor—β_1,TGF—β_1)是一种调节细胞外基质蛋白生成的多功能多肽,主要起源于血小板,正常情况下脑脊液(CSF)中缺乏,但在蛛网膜下腔出血(SAH)时可释放入蛛网膜下腔。作者最近已发现人重组TGF—β_1椎管内注射可在小鼠诱发交通性脑积水,提示CSF中存在活性型TGF—β_1。本研究目的是确定TGF—β_1与SAH后交通性脑积水的关系。 选择24例SAH病人,年龄39～78岁,平均61.2岁;男9例,女15例。1例病因未明,23例系脑动脉瘤破裂,行动脉瘤结扎术并放置脑池引流。80天内CT随访发现13例发生脑室扩大伴有脑室周围低密度,其中11例临床有痴呆、尿失禁和步态障碍,诊断为交通性脑积水,并行脑室腹膜(VP)分
Transforming growth factor β1 (TGF-β_1) is a multifunctional polypeptide that regulates the production of extracellular matrix proteins, mainly from platelets, normally lacking in cerebrospinal fluid (CSF), but under subarachnoid Hemorrhage (SAH) can be released into the subarachnoid space. The authors have recently found that intra-spinal injection of human recombinant TGF-β 1 can induce transcortical hydrocephalus in mice, suggesting the presence of active TGF-β_1 in CSF. The aim of this study was to determine the relationship between TGF-β 1 and traffic hydrocephalus after SAH. Choose 24 cases of SAH patients, aged 39 to 78 years, mean 61.2 years; 9 males and 15 females. One patient had unknown etiology, 23 patients had ruptured cerebral aneurysm, had aneurysm ligation and placed cerebral drainage. Follow-up of 80 days found that 13 cases of ventricular enlargement associated with low density around the ventricle, of which 11 cases of clinical dementia, urinary incontinence and gait disorders, diagnosed as traffic hydrocephalus, parallel ventricle peritoneal (VP) points