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目的 :观察中西医结合治疗狼疮性肾炎肾病综合征的临床疗效。方法 :1 5 5例患者随机分为两组 ,治疗组 (80例 )予以环磷酰胺、激素等及中医辨证治疗 ,对照组 (75例 )予以单纯西医治疗 ,观察两组治疗前后狼疮性肾炎 (LN)活动指标、尿蛋白、血浆白蛋白、血脂的变化及两组在复发率和不良反应发生率上的差异。结果 :治疗组总有效率 95 % ,显著高于对照组(79% ,P <0 0 5 ) ;治疗组在改善LN活动指标、尿蛋白、血浆白蛋白、血脂等方面均优于对照组(P <0 0 5 ) ;治疗组复发率与不良反应发生率分别为 8%和 3 4% ,显著低于对照组 (3 8%和68% ,P <0 0 5 )。结论 :中西医结合治疗较单纯西医治疗狼疮性肾炎肾病综合征有明显优势。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of lupus nephritis nephrotic syndrome. Methods: One hundred and fifty-five patients were randomly divided into two groups. The treatment group (80 cases) was treated with cyclophosphamide, hormone and syndrome differentiation of traditional Chinese medicine. The control group (75 cases) were treated with Western medicine alone. The lupus nephritis (LN) activity index, urine protein, plasma albumin, blood lipid changes and the difference between the two groups in the recurrence rate and the incidence of adverse reactions. Results: The total effective rate was 95% in the treatment group, which was significantly higher than that in the control group (79%, P 0 05). The treatment group was superior to the control group in improving LN activity index, urine protein, serum albumin, P <0.05). The recurrence rate and adverse reaction rate in the treatment group were 8% and 34%, respectively, which were significantly lower than those in the control group (38% and 68%, P <0 05). Conclusion: Integrative Chinese medicine treatment of lupus nephritis than simple Western medicine nephritic syndrome has obvious advantages.