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研究了秦归活络口服液治疗缺血性中风的主要药效学及其作用机理。结果表明:该药对实验性大鼠不完全性脑缺血引起的损伤有明显的保护作用,可使脑含水量减少、毛细血管通透性降低。能增加麻醉犬脑、肾及外周血流量,在增加脑血流量的同时明显降低脑血管阻力。能改善葡聚糖引起的大鼠软脑膜微循环障碍,改善血流速度及血液流态。可明显减低实验性大鼠颈总动脉血栓形成。对二磷酸腺苷及花生四烯酸诱导的家兔血小板聚集有明显的抑制作用,呈较好的量效关系。
The main pharmacodynamics and its mechanism of action of Qin Qi Huo Luo Oral Liquid in treating ischemic stroke were studied. The results showed that the drug had obvious protective effect on the damage caused by incomplete cerebral ischemia in experimental rats, which could reduce the brain’s water content and reduce the capillary permeability. It can increase brain, kidney and peripheral blood flow of anesthetized dogs, and increase cerebral blood flow and significantly reduce cerebral vascular resistance. Can improve the dextran-induced microcirculation of rat pial membrane, improve blood flow velocity and blood flow state. Can significantly reduce the experimental rat common carotid artery thrombosis. The inhibitory effect of adenosine diphosphate and arachidonic acid on platelet aggregation in rabbits showed a good dose-effect relationship.