论文部分内容阅读
目的：探讨原发性肝癌血液流变学改变及临床意义。方法：测定４５例原发性肝癌患者外周静脉血血液流变学及纤维蛋白原指标，并以４９例肝炎后肝硬化和３６例正常人作对照。结果：肝癌组血液粘滞诸指标均显著高于肝硬化组和正常组，其中肝癌Ⅲ期组（ｎ＝１７，８２．３％患者伴有门脉癌栓形成和／或肝内外血行转移）又比肝癌Ⅱ期组（ｎ＝２８）变化明显。结论：原发性肝癌患者存在高粘滞综合症，它可能有助于门脉癌栓形成和肿瘤血行转移的发生；慢性肝病患者血液流变性检测可为肝癌早期诊断提供线索。
Objective: To investigate the hemorheological changes and clinical significance of primary liver cancer. Methods: The hemorheology and fibrinogen index of peripheral venous blood were measured in 45 patients with primary liver cancer. 49 cases of posthepatitic cirrhosis and 36 normal controls were used as controls. Results: All indexes of blood viscosity in HCC group were significantly higher than those in liver cirrhosis group and normal group, in which HCC stage III group (n=17, 82.3% of patients with portal vein tumor embolus formation and/or intrahepatic and external hematogenous metastasis). It was significantly different from the stage II liver cancer (n=28). Conclusion: Hyperviscosity syndrome exists in patients with primary liver cancer. It may contribute to portal vein tumor thrombus formation and hematogenous metastasis. The detection of hemorheology in patients with chronic liver disease can provide clues for early diagnosis of liver cancer.