在人体内经乙酰化代谢的药物如异烟肼、磺胺类、氨苯砜、苯乙肼、普鲁卡因胺、肼酞嗪、硝基安定、甲基硫氧嘧啶等,均明显地受遗传因素的影响,主要与人体中肝内的N-乙酰基转移酶(N-acetytransferase)含量的先天差异有关,因而常呈现出代谢的多型性。即乙酰化代谢快型、慢型和中间型。用9.8mg/kg 剂量后,三组受试者的血浆药浓度分别大约为代谢快型者为1μg/ml、 Acetylated metabolites such as isoniazid, sulfonamides, dapsone, phenelzine, procainamide, hydralazine, nitrazepam and methylthiouracil in the human body are clearly inherited Factors, mainly in the human body with the liver N-acetyltransferase (N-acetytransferase) content of the inherent differences, which often showed a metabolic polymorphism. That acetylation metabolism fast, slow and intermediate. After the 9.8 mg / kg dose, plasma concentrations of the three groups of subjects were approximately 1 μg / ml for the metabolically fast type,