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[目的]观察急性缺血性脑卒中患者首次随机血糖、C反应蛋白(CRP)、纤维蛋白原(Fib)水平变化,并探讨其与急性脑梗塞患者中的作用及脑梗塞面积相关性,并评价其临床意义。[方法]把80例急性缺血性脑卒中患者作为脑卒中组,并根据发病3d内做CT/MRI测量梗塞灶的最大直径,又把患者分为二组:①大面积梗死组(梗死灶直径≥4cm)26例,②非大面积梗死组(梗死灶直径﹤4cm)54例,同时设定对照组80例。分别测定其首次随机血糖、C反应蛋白(CRP)、纤维蛋白原(Fib)水平。[结果](1)脑卒中组血糖、CRP和Fib水平明显高于对照组(P﹤0.01);(2)大面积梗死组与非大面积梗死组CRP、Fib与随机血糖水比较差异有统计学意义(前两者P﹤0.01,后者P﹤0.05)。[结论]血糖、CRP、Fib水平在急性缺血性脑卒中患者中明显增高,且CRP和Fib的增高程度与病情严重程度相关,证实血糖、CRP、Fib是急性缺血性脑卒中临床事件的独立危险因素,对临床评估缺血性脑卒中危险及梗死面积有一定意义。
[Objective] To observe the changes of the first random blood sugar, C-reactive protein (CRP) and fibrinogen (Fib) level in patients with acute ischemic stroke and to explore the relationship between them and the area of infarction in patients with acute cerebral infarction Evaluate its clinical significance. [Methods] Eighty patients with acute ischemic stroke were selected as the stroke group. According to CT / MRI, the maximum diameter of the infarction was measured within 3 days. The patients were further divided into two groups: ① large infarct Diameter ≥ 4cm) 26 cases, ② non-large area infarction group (infarct diameter <4cm) 54 cases, while setting the control group 80 cases. The first random glucose, C-reactive protein (CRP) and fibrinogen (Fib) levels were measured. [Results] (1) The levels of blood glucose, CRP and Fib in stroke group were significantly higher than those in control group (P <0.01). (2) There was statistical difference between CRP, Fib and random blood glucose in large area infarction group and non-large area infarction group Significance (the former two P <0.01, the latter P <0.05). [Conclusion] The levels of blood glucose, CRP and Fib were significantly increased in patients with acute ischemic stroke, and the increase of CRP and Fib were correlated with the severity of illness. It was confirmed that blood glucose, CRP and Fib were the clinical events of acute ischemic stroke Independent risk factors for clinical assessment of ischemic stroke risk and infarct size has some significance.