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为了检验长期习惯性的体育运动是否影响老年人I型和Ⅱ型T细胞因子的平衡。通过对9名老年妇女(平均年龄(63±1)岁,最大耗氧量(32.2±1.0)mL.kg-1.min-1)进行步行训练;挑选12名不进行运动训练的老年(妇女平均年龄(63±1)岁,最大耗氧量(27.8±0.9)mL.kg-1.min-1)和9名不进行运动训练的年轻妇女(平均年龄(26±1)岁,最大耗氧量(37.8±1.3)mL.kg-1.min-1);然后检测了CD4+和CD8+T细胞中IFN-γ、IL-2和IL-4的水平,并对I型和Ⅱ型T细胞进行了比较。结果:老年人运动组表达IFN-γ的CD4+细胞数目与比青年非运动组比较,差异有显著性(P<0.01);老年运动组表达IL-2的CD8+的T细胞数目与老年非运动组比较差异有显著性(P<0.05);青年组表达IL-4的CD8+细胞与老年非运动组比较,差异有显著性(P<0.01);3组中CD4+和CD8+T细胞中IFN-γ/IL-4的比率差异无显著性。实验结果显示年龄对I型和Ⅱ型T细胞的影响比运动训练对它的影响更大。
To test whether long-term habitual physical activity affects the balance of type I and type II T-cell cytokines in the elderly. Nine elderly women (mean age 63 ± 1 years old, maximum oxygen consumption (32.2 ± 1.0) mL.kg-1.min-1) were used for walking training. Twelve elderly women without exercise training The average age (63 ± 1) years old, the maximum oxygen consumption (27.8 ± 0.9) mL.kg-1.min-1) and 9 young women without exercise training (mean age (26 ± 1) years) (37.8 ± 1.3) mL.kg-1.min-1). The levels of IFN-γ, IL-2 and IL-4 in CD4 + and CD8 + T cells were detected, Cells were compared. Results: Compared with the young non-exercise group, the number of CD4 + cells expressing IFN-γ in the elderly exercise group was significantly different (P <0.01). The number of CD8 + T cells expressing IL-2 in the elderly exercise group was significantly lower than that of the elderly non-exercise group (P <0.05). There was a significant difference in the expression of IL-4 in the young group between the CD8 + cells and the elderly non-exercise group (P <0.01). The levels of IFN-γ in CD4 + and CD8 + T cells in the three groups / IL-4 ratio was no significant difference. Experimental results show that the impact of age on type I and type II T cells than exercise training on it greater impact.