基因治疗(Gene Therapy),就是在基因水平进行疾病治疗的一种方法。它是将外源正常基因导入靶细胞以纠正或补偿基因缺陷和异常引起的疾病,已达到治疗目的。慢病毒在基因治疗方面有能够将外源基因整合到非分裂细胞的基因组、具有更大的外源基因包装能力、引起插入突变的频率明显低等优点。目前的慢病毒载体系统主要由三部分载体组成:包装载体、基因转移载体和包膜蛋白表达载体。 Gene Therapy is a method of treating diseases at the genetic level. It is the introduction of foreign normal gene into target cells to correct or compensate for genetic defects and abnormalities caused by the disease, has achieved therapeutic purposes. Lentiviral gene therapy has the ability to integrate foreign genes into the genome of non-dividing cells, with a larger foreign gene packaging capacity, resulting in significantly lower frequency of insertion mutations. The current lentiviral vector system consists of three parts: packaging vector, gene transfer vector and envelope protein vector.