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目的:探讨硫酸基转移酶SULT1E1、SULT1A1基因多态性对子宫平滑肌瘤易感性的影响。方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析法检测子宫平滑肌瘤组和对照组SULT1E1基因rs3736599位点、SULT1A1基因rs9282861位点的多态性情况。结果:①病例组和对照组SULT1E1 rs3736599位点基因型分布差异有统计学意义(P=0.032),携带突变A等位基因(基因型为A/A和A/G)女性发生子宫平滑肌瘤的风险是野生型纯合子G/G女性的3.497倍(P=0.034,OR=3.497,95%CI:1.12～10.91)。②病例组和对照组SULT1A1 rs9282861位点基因型分布差异无统计学意义。结论:硫酸基转移酶SULT1E1基因rs3736599多态性可能与子宫平滑肌瘤易感性相关,携带突变A等位基因可能是子宫平滑肌瘤的危险因素。
Objective: To investigate the effect of SULT1E1 and SULT1A1 gene polymorphisms on susceptibility to uterine leiomyomas. Methods: The polymorphisms of rs3736599, SULT1A1 and rs9282861 of SULT1E1 gene in uterine leiomyoma group and control group were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: ①The distribution of rs3736599 locus of SULT1E1 in case group and control group showed statistically significant difference (P = 0.032), and women with mutation A allele (A / A and A / G genotypes) had uterine leiomyoma Was 3.497 times more likely than wild-type homozygote G / G in women (P = 0.034, OR = 3.497, 95% CI: 1.12-10.91). ② There was no significant difference in genotype distribution of SULT1A1 rs9282861 between case group and control group. CONCLUSIONS: The rs3736599 polymorphism of SULT1E1 gene may be associated with susceptibility to uterine leiomyomas. Carrying the mutation A allele may be a risk factor for uterine leiomyomas.