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已知导致凝血酶生成的两条主要途径是内源途径和外源途径。这两条途径会合于因子X。时至今日,下列凝血因子还被认为纯属内源途径,这些因子是因子Ⅻ、Ⅺ、Ⅸ、Ⅷ,激肽释放酶原和高分子量激肽原(HMWK)。早先已证明胶原能激活因子Ⅻ并产生这一假设,即正常止血机制由血管壁受损,暴露由胶原组成的皮下组织而启动,因子Ⅻ活性后又引起众所周知的“瀑布”反应,导致凝血酶及纤维蛋白原形成。一般认为外源活化途径取决于凝血活酶
The two main pathways known to cause thrombin generation are the endogenous and exogenous pathways. These two approaches converge at Factor X. To date, the following clotting factors have been considered purely endogenous. These factors are Factor XII, XI, IX, VIII, kallikrein and high molecular weight kininogen (HMWK). It has been previously demonstrated that collagen activates factor XII and produces the hypothesis that the normal hemostasis mechanism is initiated by damage to the blood vessel wall and exposure to subcutaneous tissue consisting of collagen, which in turn causes a well-known “waterfall” reaction, resulting in thrombin. And fibrinogen formation. Exogenous activation pathway is considered to be dependent on thromboplastin