论文部分内容阅读
Objective: To evaluate the clinical-pathological significance of intratumoral microvessel density (MVD) andVascular Endothelial Growth Factor (VEGF) expression inprimary liver cancer (PLC). Methods: A retrospectivestudy from 63 postoperative patients all with small PLC(diameter≤5 cm) was done. One group of 29 patientsdeveloped recurrence or metastasis within 2 years. Theother group of 34 patients had no evidence of recurrence ormethetheis within 2 years. Three sections were tuken fromeach patient. One for H.E. stoining, the other two for VEGFand Bio-UEA-I immunohistochemical staining respectively.MVD was counted by endothelial cells, which werehighlighted by Bio-UEA-I. Results: The MVD of therecurrence (or metastasis) group (49.6±29.7) weresignificantly greater than the other group (22.7±28.2)(P<0.01); The WGF positive rate of the recurrence groupwas 86.2% (25/29), the rate of the other group was 47.1%(16/34). The difference between the 2 groups wasstafistically significant (P<0.01). The stuge of the tumor, thepositive rate of satellite nodules and the positive rate of theportal vein embolus were all significantly different betweenthe 2 groups. Conclusion: Besides tumor stage, satellitenodule and portal vein embolus, the MVD and VEGF areaiso of prognostic significance.
Objective: To evaluate the clinical-pathological significance of intratumoral microvessel density (MVD) and Vascular Endothelial Growth Factor (VEGF) expression in primary liver cancer (PLC). Methods: A retrospectivestudy from 63 postoperative patients all with small PLC(diameter≤5 cm) was Done. One group of 29 patientsdeveloped recurrence or metastasis within 2 years. Theother group of 34 patients had no evidence of recurrence ormethetheis within 2 years. Three sections were tuken fromeach patient. One for HE stoining, the other two for VEGFand Bio-UEA- Results: The MVD of therecurrence (or metastasis) group (49.6±29.7) weresignificantly greater than the other group (22.7±28.2)(P). <0.01); The WGF positive rate of the recurrence groupwas 86.2% (25/29), the rate of the other group was 47.1%(16/34). The difference between the two groups wasstafistically significant (P<0.01 ). The stuge of the tumor, the positive rate of satellite nodules and the positive rate of the portal vein embolus were all significantly different between the two groups. Conclusion: The other tumor stage, satellitenodule and portal vein embolus, the MVD and VEGF areaiso of prognostic significance.