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目的:检测2型糖尿病合并骨质疏松症患者血清C肽及骨钙素(BGP)水平。方法:收集2013年2月至2014年1月本院老年病科住院治疗的2型糖尿病患者96例,按骨质疏松症诊断标准分为2型糖尿病合并骨质疏松症组(A组)和单纯2型糖尿病组(B组)。测定两组患者大转子、股骨颈、Wards区的骨密度,比较两组患者的血清甘油三酯(TG)、空腹血糖(FBG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、餐后2 h血糖(P2hBG)、空腹C肽、餐后2 h C肽及BGP水平。结果:两组患者血清TG、FBG等生化指标差异均无统计学意义(均P>0.05)。A组患者大转子、股骨颈及Wards区骨密度均显著低于B组(均P<0.05)。A组患者血清空腹C肽、餐后2 h C肽及BGP水平显著低于B组(均P<0.05)。结论:血清C肽及BGP可作为2型糖尿病合并骨质疏松症患者筛查的潜在指标。
Objective: To detect serum C-peptide and osteocalcin (BGP) in type 2 diabetic patients with osteoporosis. Methods: A total of 96 type 2 diabetic patients admitted to our hospital from February 2013 to January 2014 were enrolled in the study. Type 2 diabetic patients with osteoporosis (group A) and Simple type 2 diabetes group (B group). The BMD of the greater trochanter, femoral neck and Wards were measured in two groups. Serum TG, FBG, TC, LDL-C HDL-C, P2hBG, fasting C-peptide, postprandial 2-hour C-peptide and BGP levels. Results: The serum TG, FBG and other biochemical indexes showed no significant difference between the two groups (all P> 0.05). The BMD of the greater trochanter, femoral neck and Wards in group A were significantly lower than those in group B (all P <0.05). Serum fasting C-peptide, postprandial 2-h C-peptide and BGP levels in group A were significantly lower than those in group B (all P <0.05). Conclusion: Serum C-peptide and BGP can be used as potential markers in the screening of type 2 diabetic patients with osteoporosis.