论文部分内容阅读
给15～20克雄性小白鼠进行10天电休克处理,每天一次并在电休克前40～50分钟服用哌甲酯水溶液0.1毫升(1毫克/毫升).然后休息一天.接着进行明暗辨别学习训练,观察哌甲酯对电休克动物学习记忆影响.结果表明,服用哌甲酯的电休克小白鼠达到学会标准所需测试次数几乎比对照组减少60%(P<0.001).根据哌甲酯能提高脑内儿茶酚胺水平而电休克会降低脑内儿茶酚胺水平这种特点,本文结果提示,脑内儿茶醉胺与短时记忆有密切关系,可以考虑在临床上用其作为电休克疗法的辅助药,以减少甚至消除电休克障碍记忆这一副作用.
To 15-20 g of male mice were electroporated for 10 days, once daily and 0.1 ml (1 mg / ml) of methylphenidate aqueous solution 40 to 50 minutes before electroshock and then rest for one day. , The effect of methylphenidate on the learning and memory of electrically shocked animals was observed.The results showed that the number of tests needed to achieve the standard of learning was almost 60% less than that of the control group (P <0.001) Improve brain catecholamine levels and electrical shock will reduce the level of catecholamines in the brain of this feature, the results suggest that the brain of children with narcotic amine and short-term memory are closely related to consider the clinical use of electrical shock as an adjunct to drugs , To reduce or even eliminate the memory side effects of electrical shock disorders.