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用AgNOR定量法(计算AgNOR平均量/每核、数目、大小、位置及异形率)观察了78例肺癌(30例鳞癌、6例小细胞癌、31例腺癌、11例大细胞癌)病人的石蜡切片。结果表明,AgNOR颗粒有三种类型的形态特征:孤立圆形、细小弥漫型、粗大不规则型;每型肺癌有各自的一些形态特征;高分化腺癌细胞AgNOR平均数与其他类型肺癌相差非常显著(P<0.01);随着分化程度降低肺癌细胞AgNOR颗粒数增加、变细小或粗大不规则。作者认为,AgNORs颗粒数增加及不规则可能与基因调控、细胞增殖活性,核仁聚散等有关,对肺癌分型诊断有一定的帮助。
Eighty-seven patients with lung cancer (30 squamous cell carcinomas, 6 small cell carcinomas, 31 adenocarcinomas, and 11 large cell carcinomas) were observed using the AgNOR quantification method (average AgNOR/core, number, size, location, and heteromorphism). Patient’s paraffin section. The results showed that AgNOR particles have three types of morphological characteristics: isolated round, small and diffuse, and large and irregular; each type of lung cancer has its own morphological characteristics; the average AgNOR of well-differentiated adenocarcinoma cells is very different from that of other types of lung cancer. (P<0.01); As the degree of differentiation decreased, the number of AgNOR particles in lung cancer cells increased, became fine, or became thick and irregular. The authors believe that the increased number and irregularity of AgNORs particles may be related to gene regulation, cell proliferation activity, nucleolar aggregation, etc., which may help in the diagnosis of lung cancer type.