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目的观察奥拉西坦联合高压氧治疗颅脑损伤的临床效果。方法 90例颅脑损伤患者随机分为观察组和对照组各45例,在常规治疗基础上,观察组给予奥拉西坦联合高压氧治疗,对照组静脉滴注奥拉西坦,2组均连续治疗21d。比较2组治疗前、后格拉斯哥昏迷量表(Glasgow Coma Scale,GCS)、意识觉醒恢复时间及疗效,观察2组治疗后简易精神状态检查量表(Minimum Mental State Examination,MMSE)和神经功能缺损评分表(National Institutes of Health Stroke Scale,NIHSS)变化。结果观察组总有效率(88.89%)高于对照组(73.11%),意识觉醒恢复时间((6.29±0.94)d)短于对照组((8.16±0.82)d)(P<0.01);2组治疗后GCS评分均较治疗前增高(P<0.05);观察组治疗后MMSE评分((22.38±0.96)分)高于对照组((21.64±1.15)分)(P<0.01),NIHSS评分((10.80±1.16)分)低于对照组((12.87±0.92)分)(P<0.01);2组均未发生不良反应。结论奥拉西坦联合高压氧治疗颅脑损伤疗效优于单独应用奥拉西坦,且无不良反应。
Objective To observe the clinical effect of oxiracetam combined with hyperbaric oxygen on craniocerebral injury. Methods 90 patients with craniocerebral injury were randomly divided into observation group and control group, 45 cases. On the basis of routine treatment, the observation group was treated with oxiracetam combined with hyperbaric oxygen. The control group received intravenous oxiracetam. Continuous treatment 21d. The Glasgow Coma Scale (GCS), consciousness recovery recovery time and curative effect were compared between the two groups before and after treatment. The scores of MMSE and MMSE were compared between the two groups before and after treatment. Table (National Institutes of Health Stroke Scale, NIHSS) changes. Results The total effective rate (88.89%) in the observation group was significantly higher than that in the control group (73.11%), and the recovery time of consciousness awakening (6.29 ± 0.94) d was shorter than that in the control group (8.16 ± 0.82) d (P <0.01) The score of GCS after treatment was higher than that before treatment (P <0.05). MMSE score (22.38 ± 0.96) in the observation group after treatment was significantly higher than that in the control group (21.64 ± 1.15) (P <0.01) (10.80 ± 1.16) points lower than the control group (12.87 ± 0.92) points (P <0.01). No adverse reactions occurred in the two groups. Conclusion Oxiracetam combined with hyperbaric oxygen treatment of craniocerebral injury is superior to oxiracetam alone, and no adverse reactions.