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通过术前检测原发性大肠癌（７４例）、大肠良性病（３０例）和正常健康人（４０例）周围静脉血清中ＣＡ＿（５０）水平（单抗ＩＲＭＡ法），发现大肠癌组明显高于大肠良性疾病组（Ｐ＜０．０１）和正常组（Ｐ＜０．０１）．以正常人均数加两倍标准差为界值（１４．０７μ／ｍｌ），大肠癌阳性率为５５．４％（Ａ期２８．６％、Ｂ期４８．１％、Ｃ期５０％、Ｄ期８７．５％）。此外，ＣＡ＿（５０）水平在大肠癌Ｄｕｋｅｓ’分期中（Ａ７例、Ｂ期２７例、Ｃ期２４例、Ｄ期１６例），Ｄ期明显高于其它各期（Ｐ＜０．０１），而Ａ、Ｂ、Ｃ期之间无统计学意义（Ｐ＞０．２５）。肿瘤环绕肠管程度超过１／２者，ＣＡ＿（５０）水平高于未超过１／２者（Ｐ＜０．０１）。根治性手术者ＣＡ＿（５０）水平低于姑息性手术者（Ｐ＜０．０１）。ＣＡ＿（５０）水平正常者无一例肝转移；有肝转移者ＣＡ＿（５０）水平高于无肝转移者（Ｐ＜０．０１）。
Preoperative detection of primary colorectal cancer (74 cases), benign colorectal disease (30 cases) and normal healthy people (40 cases) peripheral blood serum levels of CA50 (monoclonal antibody IRMA method), found that the colorectal cancer group was significantly Higher than the colorectal benign disease group (P <0.01) and normal group (P <0.01). With a standard deviation of the normal number of patients plus twice the standard deviation (14.07μ/ml), the positive rate of colorectal cancer was 55.4% (28.6% in period A, 48.1% in period B, 50% in period C, and D). Period 87.5%). In addition, CA_(50) levels were significantly higher in the Dukes’ stage of colorectal cancer (A7, B, 27, C, 24, and D, D) than in the other phases (P<0.01). There was no significant difference between A, B and C phases (P>0.25). Tumor surrounding the intestine was more than 1/2, and the level of CA_(50) was higher than that of no more than 1/2 (P<0.01). The level of CA_(50) in radical surgery was lower than that in palliative surgery (P<0.01). There was no liver metastasis in patients with normal CA 50 levels; CA 50 levels in patients with liver metastases were higher than those without liver metastases (P < 0.01).