La/Ce0.5Mn0.5 catalysts prepared by wetness impregnation of Ce0.5Mn0.5 with La(NO3)3 (aq) were used in catalytic oxidation of ethyl acetate.Characterization by X-ray diffractometer (XRD),H2 temperature programmed reduction (H2-TPR),X-ray photoelectron spectroscopy (XPS) and Raman shows that La/Ce0.5Mn0.5 catalysts have fluorite-like structure.La/Ce0.5Mn0.5 catalyst presents high activity with T90 (the temperature needed for 90％ conversion) of 200 ℃,where ethyl acetate is almost completely converted into CO2.The conversion at 195 ℃ maintains at 80％ for at least 100 h.The intermediates were mainly ethanol and acetaldehyde whose amounts are below 250 × 10-6 and 16 × 10-6,respectively.In situ FTIR indicates that the modes of dissociative adsorption of ethyl acetate are related to surface oxygen species,which affect the stability of catalysts and the selectivity for ethanol and acetaldehyde intermediates.