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对20例高血压病(EH)患者拉西地平治疗前及治疗4周后,分别进行口服葡萄糖耐量试验(OGTT).并测定治疗前后血糖(SG)、血胰岛素(IS),与18例正常人(其年龄、体重指数相当)比较,结果:(1)降压作用:EH 组拉西地平治疗后血压较治疗前有显著降低(SBp:18.76±1.74kPa 比22.72±1.35kPa、DBp:11.76±1.23kPa 比14.31±1.14kPa)(P<0.05),总有效率达95%;(2)对 SG 影响:空腹血糖 EH 组较对照组无明显变化(P>0.05),OGTT 后 EH 组出现糖耐量异常达65%,治疗后血糖较治疗前略有下降,但无统计学差异;(3)对 IS 影响:EH 组血IS 空腹及 OGTT 后水平较对照组明显增高(P<0.05),IS/SG 比值空腹及 OGTT 后较对照组明显增高(P<0.05),IS 敏感性较对照组下降(0.11±0.03比0.19±0.03),EH 组拉西地平治疗后 IS 较治疗前下降。以0.5～1h 明显(0.5h:57.07±12.24mu/L 比77.26±14.49mu/L;1h:68.55±13.79mu/L 比90.09±15.25mu/L),(P<0.05),IS 敏感性较治疗前增加(0.14±0.06比0.11±0.03)。提示:EH 患者存在高胰岛素血症;拉西地平降压同时也降低了血 IS,增加了 IS 敏感性,使胰岛素抵抗得到了改善。
The oral glucose tolerance test (OGTT) was performed before and after the treatment of lacidipine in 20 patients with essential hypertension (EH), and the blood glucose (SG), insulin (IS) (Age, body mass index), the results: (1) antihypertensive effect: Eh group after lacidipine treatment blood pressure was significantly lower than before treatment (SBp: 18.76 ± 1.74kPa than 22.72 ± 1.35kPa, DBp: 11.76 ± 1.23 kPa vs 14.31 ± 1.14 kPa) (P <0.05), and the total effective rate was 95%. (2) Effect on SG: There was no significant change in fasting blood glucose EH group compared with control group (P> 0.05) (3) The effect on IS: Compared with the control group, the level of fasting blood glucose and OGTT in EH group was significantly higher than that in the control group (P <0.05), while the IS / SG ratio was significantly higher in fastigial and OGTT groups than in control group (P <0.05). IS sensitivity was significantly lower in IS group than in control group (0.11 ± 0.03 vs 0.19 ± 0.03), and IS in EH group was lower than that in control group after treatment with lacidipine. (0.5h: 57.07 ± 12.24mu / L vs 77.26 ± 14.49mu / L; 1h: 68.55 ± 13.79mu / L vs 90.09 ± 15.25mu / L, P <0.05) Before treatment increased (0.14 ± 0.06 vs 0.11 ± 0.03). Tip: EH patients with hyperinsulinemia; raxidipine also reduced blood pressure IS, increased IS sensitivity, so that insulin resistance has been improved.