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循环肿瘤细胞(circulating tumor cells,CTCs)指的是从实体的肿瘤或转移的病灶进入外周血液循环的恶性肿瘤细胞。自发现以来,随着其检验技术日趋成熟,循环肿瘤细胞(CTCs)日渐成为肿瘤学炙手可热的研究对象。因为它将通过外周血的检验来实现监测肿瘤的发生、发展、转移、复发等情况,相对于肿瘤实体活检,“液体活检”不仅让患者易于接受,更有利于医务工作者监测病情变化。本文综述了循环肿瘤细胞(CTCs)的检测方法并综述了循环肿瘤细胞在女性实体肿瘤--乳腺癌、卵巢癌、宫颈癌、子宫内膜癌中的研究进展。其中着重介绍了其在早期乳腺癌及复发转移性乳腺癌中的重大意义以及在评价治疗效果中的分子学特征。实践表明,循环肿瘤细胞(CTCs)与HE-4、CA125的联合应用在评估卵巢癌化疗敏感性中也具有重要的临床意义。
Circulating tumor cells (CTCs) refer to malignant tumor cells that enter the peripheral bloodstream from solid tumors or metastatic lesions. Since its discovery, circulating tumor cells (CTCs) have increasingly become a hot topic in oncology as their testing technology matures. Because it will be through the detection of peripheral blood to monitor the occurrence of tumor, development, metastasis, recurrence, etc., compared to the biopsy of the tumor, “liquid biopsy ” not only allows patients to be easily accepted, but also more conducive to monitoring changes in medical conditions . This article reviews the detection methods of circulating tumor cells (CTCs) and reviews the progress of circulating tumor cells in solid tumors of women - breast cancer, ovarian cancer, cervical cancer and endometrial cancer. It focuses on its significance in early breast cancer and recurrent metastatic breast cancer as well as its molecular characteristics in evaluating the therapeutic effect. Practice shows that the combination of circulating tumor cells (CTCs) and HE-4, CA125 in the evaluation of the sensitivity of ovarian cancer chemotherapy also has important clinical significance.