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目的探讨月经生育史对可手术乳腺癌病人的预后的影响。方法以１９７７～１９８３年期间我院可手术４１２例乳腺癌为研究对象，根据病人年龄、绝经已否、初潮及绝经年龄，及生育与妊娠次数分别计算其十年生存率，然后用Ｃｏｘ模型法对病人生育因素及传统的预后因素（肿瘤大小、淋巴结状态）进行多变量分析。结果未曾妊娠及生育的妇女预后较好（６４％比５４％Ｐ＝０．０１，６２％比５３％Ｐ＝０．００５），生存率随妊娠及产次的增加而降低。多变量分析结果提示生育次数与传统预后因素一样是一个独立的预后因素。结论众所周知，生育因素是乳腺癌重要的危险因素之一，其作用表现为生育次数与乳腺癌的危险性呈负相关，但对已患乳腺癌患者的预后产生不良作用
Objective To investigate the influence of menstrual birth history on the prognosis of operable breast cancer patients. Methods A total of 412 cases of breast cancer were studied in our hospital from 1977 to 1983. The 10-year survival rate was calculated according to the age of the patient, menopause or not, menarche and age of menopause, and the number of births and pregnancy. Then the Cox model method was used. Multivariate analysis of patient fertility factors and traditional prognostic factors (tumor size, lymph node status). Results The pregnancies and fertility women had a better prognosis (64% vs. 54% P=0.01, 62% vs. 53% P=0.005), and the survival rate decreased with increasing pregnancies and parity. The results of multivariate analysis suggest that the number of births is an independent prognostic factor as well as traditional prognostic factors. Conclusion It is well-known that fertility factors are one of the important risk factors for breast cancer. Its role is that the number of births is negatively correlated with the risk of breast cancer, but it has an adverse effect on the prognosis of patients with breast cancer.