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Research into the suppressive activity of CD4+FoxP3+ T regulatory cells (Treg) has defined a sublineage of CD4+ cells that contribute to self-tolerance and resistance to autoimmune disease. Much less attention has been given to the potential contribution of regulatory sublineages of CD8+ cells. Analysis of a small fraction of CD8+ cells that target autoreactive CD4+ cells through recognition of the MHC class Ib molecule Qa-1 in mouse and HLA-E in human has revitalized interest in CD8+ Treg. Here we summarize recent progress and future directions of research into the role of this CD8+ sublineage in resistance to autoimmune disease.
Research into the suppressive activity of CD4 + FoxP3 + T regulatory cells (Tregs) has defined a sublineage of CD4 + cells that contribute to self-tolerance and resistance to autoimmune disease. Much less attention has been to the potential contribution of regulatory sublineages of CD8 + cells . Analysis of a small fraction of CD8 + cells that target autoreactive CD4 + cells through recognition of the MHC class Ib molecule Qa-1 in mouse and HLA-E in human has revitalized interest in CD8 + Treg. Here we summarize recent progress and future directions of research into the role of this CD8 + sublineage in resistance to autoimmune disease.