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十二指肠溃疡的治疗除组织胺H_2受体拮抗剂外,已知几种其它药物有效。这些药物不仅可以促进溃疡愈合,还能缓解疼痛,并能预防溃疡复发。硫糖铝硫糖铝(sucralfate)是蔗糖的碱基铝盐被8个硫酸基团取代后的产物。几乎不溶于水,能发生碱性反应。当药物遇到胃内的酸性环境时(pH<3～4),一些Al_2(OH)_5~+离子从蔗糖8硫酸分子中分离出来,剩下的复合物变为带负电。推测蔗糖8硫酸分子发生聚合作用,形
Treatment of duodenal ulcers In addition to histamine H 2 receptor antagonists, several other drugs are known to be effective. These drugs not only promote ulcer healing, but also relieve pain and prevent ulcer recurrence. Sucralfate is the product of the replacement of the basic aluminum salt of sucrose by 8 sulfate groups. Almost insoluble in water, can occur alkaline reaction. When the drug encounters an acidic environment in the stomach (pH <3-4), some of the Al 2 (OH) 5 ~ + ions are separated from the sucrose 8 sulfate molecule and the remaining compound becomes negatively charged. Speculated sucrose 8 sulfuric acid polymerization occurs, the shape