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目的:优选护肝颗粒水提工艺。方法:应用HPLC和正交试验,以护肝颗粒中活性成分虎杖苷提出量、全方收膏率的综合评分为考察指标,以提取时间、提取次数、加水量3个因素设计L9(34)正交试验优选护肝颗粒水提工艺。结果:最佳水提工艺为加10倍量水回流提取2次,每次1 h。结论:优选的提取工艺稳定可靠,可用于护肝颗粒的生产制备。
Objective: To optimize water extraction technology of Hugan granules. Methods: HPLC and orthogonal test were used to determine the amount of the active ingredient in Hugan granule and the total score of the total ginseng extract. The time, the number of extraction and the amount of water were used to design L9 (34) Orthogonal test optimization of liver protection particles water extraction process. Results: The best water extraction process for 10 times the amount of water reflux extraction 2 times, each 1 h. Conclusion: The optimal extraction process is stable and reliable, which can be used for the preparation of Hugan granule.