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喹诺酮类临床应用不断扩大,不良反应报道也愈见增多。现将喹诺酮类药物临床使用须注意的问题作一简要说明,供临床用药参考。 1 抗菌机制方面 杀菌动力学试验显示,随着喹诺酮浓度增加,杀菌作用增强,活菌数逐渐减少,但达到最大杀菌浓发后,药物浓度进一步增加反使抗菌作用降低,活菌数增加。用~3H标记尿嘧啶、亮氨酸研究表明,喹诺酮类在高浓度时有抑制细菌RNA及蛋白质合成的作用。用氨基酸或尿嘧啶饥饿试验及氯霉素
Quinolones clinical applications continue to expand, more and more reports of adverse reactions. Now Quinolones clinical use should pay attention to a brief description of the problems for clinical use of reference. 1 Antibacterial mechanism of bactericidal kinetics tests showed that with the increase of quinolone concentration, bactericidal effect increased, the number of viable cells gradually decreased, but after reaching the maximum bactericidal concentration, the drug concentration further increased anti-bacterial effect decreased, the number of viable cells increased. ~ 3H labeled uracil, leucine studies have shown that quinolones inhibit bacterial RNA and protein synthesis at high concentrations. Starvation with amino acids or uracil test and chloramphenicol