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病灶内药物的理想浓度,对提高抗结核化疗效果,具有一定的意义。在这方面的研究已经证明,支气管内滴注是合适的,作者首先在80只大白鼠应用利福平支气管内滴注与口服,于2、4、8、12小时后分别测定其肺组织中的利福平浓度,并进行比较。另对经利福平治疗的34例空洞性肺结核的手术切除标本(其中14例术前曾支气管内滴注利福平,20例只用口服),分别测定其肺健康组织中和空洞壁上的利福平浓度,进行对比。在此基础上,作者对182例经一、二线药物化疗无效的空洞性肺结核,应用利福平支气
The ideal concentration of the drug in the lesion has a certain significance for improving the effect of anti-tuberculosis chemotherapy. Studies in this area have demonstrated that endobronchial instillation is appropriate. The authors first used rifampicin instillation and orally in 80 rats and measured their lung tissue 2, 4, 8 and 12 hours later. Rifampicin concentration and compare. In addition, surgical specimens of 34 cases of vacated pulmonary tuberculosis treated with rifampicin (including 14 cases of rifampicin instillation before bronchial intubation and 20 cases of oral administration only) were used to measure the lung tissue and the cavity wall. The concentration of rifampicin was compared. On this basis, the authors applied rifampicin on 182 cases of vacant pulmonary tuberculosis that was not responding to first- and second-line drug chemotherapy.