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目的：研究胃小细胞癌（ＳＣＣＳ）的临床病理特征。方法：对２２例ＳＣＣＳ的病理形态进行观察，１４例做神经元特异性烯醇化酶（ＮＳＥ）、嗜铬素Ａ（ＣｇＡ）、癌胚抗原（ＣＥＡ）、细胞角蛋白（ｃｙｔｏｋｅｒａｔｉｎ）免疫组织化学染色，６例做电镜观察。结果：ＳＣＣＳ占同期胃癌的２．５％（２２／１６００例），中、晚期浸润性癌占９５．４％。在ＳＣＣＳ分型中复合型１２例，纯小细胞癌６例，混合性２例。有淋巴结转移的１９例，侵犯脉管１０例，侵犯神经５例，术中发现肝转移１例，远处淋巴结（大网膜、腹主动脉旁）转移１例。小细胞成分ＮＳＥ、ＣｇＡ轻～中度表达、腺或鳞癌分化区域ＣＥＡ、ｃｙｔｏｋｅｒａｔｉｎ轻至中度表达。３例电镜下找到神经内分泌颗粒。结论：ＳＣＣＳ同肺小细胞癌一样，是高度恶性的神经内分泌癌，并伴有多向分化的特征，应与胃低分化腺癌区分
Objective: To study the clinicopathological features of gastric small cell carcinoma (SCCS). Methods: Twenty-two cases of SCCS were observed for pathological morphology, and 14 cases were subjected to neuron-specific enolase (NSE), chromogranin A (CgA), carcinoembryonic antigen (CEA), and cytokeratin immunohistochemistry. Staining, 6 cases were observed under electron microscope. RESULTS: SCCS accounted for 2.5% (22/1600) cases of gastric cancer during the same period, and 95.4% of invasive carcinomas of the middle and late stages. In the SCCS classification, there were 12 cases of complex type, 6 cases of pure small cell carcinoma, and 2 cases of mixed type. There were 19 cases with lymph node metastasis, 10 cases with invasion of the vasculature, and 5 cases with invading nerves. One case was found with hepatic metastasis during surgery, and one case was located in distant lymph nodes (optic retina and paraaorta). Small cell components NSE, CgA light to moderate expression, glandular or squamous cell carcinoma differentiation areas CEA, cytokeratin light to moderate expression. Three cases of neuroendocrine particles were found under electron microscope. CONCLUSIONS: SCCS, like small cell lung cancer, is a highly malignant neuroendocrine carcinoma with multilineage characteristics and should be differentiated from poorly differentiated adenocarcinoma of the stomach.