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维生素B_(12)及叶酸是造血不可缺少的物质,机体内这些维生素缺乏与贫血的发生有关,特别是引起巨幼红细胞性贫血。另外,血中维生素B_(12)含量异常增加即所谓高维生素B_(12)血症,引起慢性骨髓性白血病(CML)、急性前骨髓细胞性白血病(APL),急性骨髓性白血病(AML),急性肝功能损害可见血中维生素B_(12)值非常高,故对此类疾病的诊断很有意义。维生素B_(12)及叶酸测定以往多采用微生物定量分析法。近年来由于同位素示踪物应用于临床,现维生素B_(12)及叶酸的测定均用同位素示踪法,即用~(57)Co 标记维生素,~(75)Se 或~(125)I 标记叶酸,其测定的准确性及临
Vitamin B_ (12) and folic acid are indispensable materials for hematopoiesis. The deficiency of these vitamins in the body is related to the occurrence of anemia, especially megaloblastic anemia. In addition, the abnormal increase of vitamin B 12 in the blood is called hypervitamin B 12 hyperlipidemia, which causes chronic myelogenous leukemia (CML), acute pre-myeloid leukemia (APL), acute myeloid leukemia (AML) Acute liver damage can be seen in the blood vitamin B_ (12) value is very high, so the diagnosis of such diseases is of great significance. Vitamin B_ (12) and folic acid in the past, the use of microbial quantitative analysis. In recent years, due to the clinical application of isotope tracers, vitamin B 12 and folic acid are both detected by isotope tracer, labeled with ~ (57) Co, vitamins, ~ (75) Se or ~ (125) I Folate, the accuracy of its determination and Pro