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目的 本研究应用放射性显像剂18F FP CIT进行脑PET显像来评价脑内的DA能系统的功能变化 ,并从安全性、有效性等方面对本方法进行评价。方法 分别对猴、正常人和不同程度的帕金森病患者应用18F FP CIT进行脑PET显像 ,观察其安全性和在不同程度PD患者的图像表现。结果 正常猴 1h断层图像上脑内双侧尾状核和壳核出现较高的放射性浓聚 ;3h双侧纹状体放射性相对更为浓聚。正常人 15min和 3 0min脑断层图像上双侧尾状核和壳核出现放射性摄取 ,同时大脑皮层有一定程度的放射性摄取 ,2h图像已非常清晰 ,仅尾状核和壳核清晰可见。 5 7例PD患者PET图像中 ,PD患者症状与对侧脑后壳核放射性的降低明显相关。结论 DAT显像可从分子水平评价多巴胺递质系统功能的客观情况 ,是有很好临床价值的分子影像学手段
Objective In this study, radioactive imaging agent 18F FP CIT was used to evaluate the brain function of DA energy system in brain PET imaging. The safety and efficacy of this method were also evaluated. Methods 18F FP CIT was used in monkey, normal people and patients with different degrees of Parkinson’s disease respectively to observe the safety of the brain and the imaging manifestations of PD patients with different degrees. Results In normal 1h imaging, the bilateral caudate nucleus and putamen in brain showed higher radioactive concentration. The radioactivity of bilateral striatum in 3h was more concentrated. Radiation uptake was observed in the bilateral caudate nucleus and putamen on 15 min and 30 min brain sections of normal subjects, while the cerebral cortex had a certain degree of radioactivity uptake. The images were very clear at 2 h, and only the caudate and putamen were clearly visible. In PET images of 57 PD patients, the symptoms of PD were significantly associated with the decreased radioactivity in the contralateral posterior putamen. Conclusion DAT imaging can evaluate objectively the function of dopamine neurotransmitter system at the molecular level and is a molecular imaging method with good clinical value