论文部分内容阅读
目的：探讨脑脊液铜、锌及铜锌比值在中枢神经系统白血病中的临床意义。方法：选择１９９３ 年～１９９７年的３５ 例患者，其中急性非淋巴细胞白血病１０ 例，急性淋巴细胞白血病２５例，伴中枢系统白血病（ＣＮＳＬ）１５ 例，其中急性淋巴细胞白血病１３ 例，急性非淋巴细胞白血病Ｍ５ 型２ 例，后选择妇科、骨科、普外科年龄相近的２０ 例患者作对照组，所有病例均排除肿瘤及中枢神经系统病变，采集３ｍ Ｌ脑脊液采用美国ＰＥＲＫＩＮ－ ＥＩＭＥＲ６５００ 至感应藕合等离子发射光谱仪测定后用ｔ检验分析。结果：ＣＳＦ—Ｃｕ 的测定结果，ＣＮＳＬ组与对照组比较有显著性差异（Ｐ＜ ０．０１），非ＣＮＳＬ组与对照组比较无显著性差异（Ｐ＞ ０．０５），ＣＮＳＬ组与非ＣＮＳＬ组比较有显著性差异（Ｐ＜ ０．０１）。ＣＳＦ—Ｚｎ 的测定结果，ＣＮＳＬ组与对照组比较有显著性差异（Ｐ＜ ０．０１），非ＣＮＳＬ组与对照组比较，无显著性差异（Ｐ＞ ０．００５），ＣＮＳＬ与非ＣＮＳＬ组比较，有显著性差异（Ｐ＜ ０．０１）。ＣＳＦ—Ｃｕ／Ｚｎ 比，１２ 例ＣＮＳＬ患者治疗完全缓解时，ＣＳＦ—Ｃｕ／Ｚｎ 与正常对照组相近，但低于治疗前和复发后，缓解时于治疗前和复发后有显著差异（Ｐ＜
Objective: To explore the clinical significance of cerebrospinal fluid ratio of copper, zinc and copper to zinc in leukemia of the central nervous system. METHODS: Thirty-five patients from 1993 to 1997 were selected. Among them, 10 were acute non-lymphocytic leukemia, 25 were acute lymphocytic leukemia, 15 were CNSL, 13 were acute lymphoblastic leukemia, and the other was acute non-lymphatic. Two patients with cell leukemia M5 type were selected and 20 patients with similar ages in gynecology, orthopaedics, and general surgery were selected as the control group. All cases were excluded from tumor and central nervous system lesions. 3m L of cerebrospinal fluid was collected from the US PERKIN-EIMER6500 to induction-coupled plasma. The emission spectrometer was measured and analyzed by t test. Results: The results of CSF-Cu were significantly different between the CNSL group and the control group (P<0.01). There was no significant difference between the non-CNSL group and the control group (P> 0.05). CNSL group and non-CNSL group There was a significant difference in the CNSL group (P < 0.01). The results of CSF-Zn assay showed a significant difference between the CNSL group and the control group (P<0.01). There was no significant difference between the non-CNSL group and the control group (P> 0.005). CNSL and non-CNSL groups For comparison, there was a significant difference (P < 0.01). In the CSF-Cu/Zn ratio, when 12 patients with CNSL received complete remission, CSF-Cu/Zn was similar to the normal control group, but lower than before treatment and after relapse, and there was a significant difference between before treatment and after relapse during remission (P<