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采用５种不同的化学减毒方法对无细胞百日咳菌苗的ＰＴ组分减毒效果进行了比较研究，选择出对菌苗的抗原性破坏小、减毒效果确切、减毒时不产生变性蛋白凝块的改进的甲醛减毒方法。
Five different methods of chemical attenuating were used to compare the attenuating effect of PT component of acellular pertussis vaccine. The results showed that the antigenicity of the vaccine was small, the attenuating effect was exact and no denatured protein Improved method of reducing formaldehyde in clots.