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AIM:To explore the role of Helicobacter pylori(H pylori) infection on the risk of digestive tract cancers. METHODS:In total,199 oral squamous-cell carcinoma(SCC),317 esophageal SCC,196 gastric cardia and non-cardia adenocarcinoma and 240 colon adenocarcinoma patients were recruited for serum tests of H pylori infection.Two hospital-and one community-based control groups were used for the comparisons.H pyloriseropositivity was determined by an enzyme linked immunosorbent assay method against H pylori IgG. RESULTS:Presence of H pylori infection was significantly inversely associated with esophageal SCC[adjusted odds ratio(AOR):0.315-0.472,all P-value< 0.05]but positively associated with gastric adenocarcinoma(both cardia and non-cardia)(AOR:1.636-3.060, all P-value<0.05)in comparison to the three control groups.Similar results were not found in cancers of the oral cavity and colon. CONCLUSION:Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk,but increases the risk of gastric cardia adenocarcinoma.
AIM: To explore the role of Helicobacter pylori (H pylori) infection on the risk of digestive tract cancers. METHODS: In total, 199 oral squamous-cell carcinoma (SCC), 317 esophageal SCC, 196 gastric cardia and non-cardia adenocarcinoma and 240 colon adenocarcinoma patients were recruited for serum tests of H pylori infection. Two hospital-and one community-based control groups were used for the comparisons. H pyloriseropositivity was determined by an enzyme linked immunosorbent assay method against H pylori IgG. RESULTS: Presence of H pylori infection was significantly inversely associated with esophageal SCC [adjusted odds ratio (AOR): 0.315-0.472, all P-value <0.05] but positively associated with gastric adenocarcinoma (both cardia and non- cardia) (AOR: 1.636-3.060, all P-value <0.05) in comparison to the three control groups.Similar results were not found in cancers of the oral cavity and colon. CONCLUSION: Our findings support the finding that H pylori seropositivity is inversely associated with esoph ageal SCC risk, but increases the risk of gastric cardia adenocarcinoma.