测定有机化合物的立体结构,手性光谱技术——圆二色谱或旋光谱是常用的方法,它具有简便易行,省时间,用量小,结果可靠等优点。在具体应用中,需根据所测cotton效应谱线的符号,遵守特定手性规则,即可确定绝对立体结构。如,环酮体系中的“八区律”,已被广泛应用,且可靠性强;另外,双烯的“螺旋规则”,内酯环的“环手性规则”等也被应用。近些年发展 Determination of the three-dimensional structure of organic compounds, chiral spectroscopy - circular dichroism or spin spectroscopy is a commonly used method, which has the advantages of simple and easy, save time, small dosage, reliable results. In a specific application, the absolute three-dimensional structure can be determined according to the sign of the measured cotton effect line and by observing specific chiral rules. For example, the “eight-zone law” in the cyclic ketone system has been widely used and has high reliability. In addition, “helical rules” of dienes and “cyclic chiral rules” of lactone rings are also applied. In recent years development