神经肽Y是哺乳动物中枢和周围神经系统中最丰富的一种肽类介质,大量动物实验证明其对下丘脑-垂体-性腺轴有一定的调节作用,在卵巢组织中,高浓度的神经肽Y也提示其在卵巢功能中起一定的作用。为研究神经肽Y对培养的颗粒细胞分泌功能的影响,选择16例27～36岁妇女,有自然排卵周期,因单或双侧输卵管不通或男方因素不孕。 Neuropeptide Y is one of the most abundant peptide mediators in the mammalian central nervous system and peripheral nervous system. A large number of animal experiments have shown that it has a regulatory effect on the hypothalamic-pituitary-gonadal axis. In ovarian tissues, neuropeptide Y Y also suggests that it plays a role in ovarian function. In order to study the effect of neuropeptide Y on the secretion of cultured granulosa cells, 16 women aged 27-36 years were selected and had spontaneous ovulation cycle because of unilateral or bilateral tubal failure or male infertility.